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Cushing’s disease is a rare condition that is caused when the body is exposed to high hormone cortisol for a long period. Also known as hypercortisolism, this disease is usually caused when the body produces too much cortisol hormone. Cortisol is a hormone that is essential for the smooth functioning of the body and is made by the adrenal glands. It largely affects body tissues and controls the body’s use of nutrition such as proteins and fats. It is necessary to help an individual deal with situations that include illnesses and stress.
Cushing’s disease can cause several complications such as an increase in blood pressure, loss of bone density and in some cases Type 2 diabetes. The Cushing’s disease symptoms depend on the levels of cortisol produced in the body. Here are few typical Cushing’s disease symptoms that may be experienced by an individual who suffers from the condition:
Gain in body weight – Increase in body weight is one of the most common Cushing’s disease symptoms. An individual begins to suddenly bloat, especially in the upper parts of the body. This includes the arms, chest, and abdomen.
Back-hump – A lump begins to form in the upper portion of the back, between the shoulders. This lump tends to increase in size with each passing day.
Acne – Acne may appear on the face and the back. It may also develop around the shoulders and the breast area. However, this symptom is not a major indicator, and acne develops in the later stages.
Stretch marks – The development of stretch marks on the skin of the body is one of the popularly reported Cushing’s disease symptoms. Unlike typical stretch marks, the pinkish purple stretch marks develop on the abdomen, thighs, breast, and arms.
Slow healing – There is a delay in the natural process of healing. Wounds that are caused by cuts, insect bites and infections take a long while to heal.
Irregular menstrual cycle – One of the most common Cushing’s disease symptoms in women includes an irregular or absent period cycle.
Fatigue and weakness – People who suffer from the condition are bound to experience fatigue. The muscles feel weak and there is lack of enthusiasm. Most importantly, one loses control over emotions and tends to slip into depression and anxiety.
Not all people will have the same symptoms and signs. While one individual may have mild symptoms, the other may suffer from more severe symptoms. In case one notices any of the symptoms, consulting a medical professional as soon as possible is essential.
Pulmonary Fibrosis is a chronic malady whose exact cause is unknown and therefore, it is termed idiopathic. In this progressively worsening condition, the lungs get scarred, and the healing process for unknown reasons repairs the damage with scar tissue, an inelastic fibrous connective tissue. These scar tissues cannot be replaced. Pulmonary fibrosis is not very uncommon. The individual types are rare and difficult to identify.
It is believed that various factors interact in the development of this disease, with heredity having an important role. Exposure to certain toxic chemicals, certain medications, and medical conditions, coal and silica dusts, asbestos fiber, heavy metal dust, radiation therapy, grain dust, and animal and bird dropping are all the major contributors. Long term smoking also seems to be a factor. With loss of elasticity the lungs cannot expand and contract restricting breathing. Loss of normal tissue affects the gas transfer resulting in shortage of oxygen in blood. As the disease progresses the lung becomes more and more scar tissue and restricts the blood flow leading to pulmonary hypertension which drags the heart into complications.
The disease normally starts with shortness of breath, inability to breathe deep, and reached a stage when breathing itself becomes painful. Constant tiredness, a dry hacking cough, weight loss which has no discernable cause, ache in muscles and joints and clubbing of fingers and toes are other symptoms of pulmonary fibrosis. The intensity of symptoms and the course of the disease vary widely among patients.
The progress of the disease can, in some cases, be slowed down by some modern drugs like pirfenidone and nintedanib the former produces rashes, nausea and diarrhea while the latter produces diarrhea and nausea. There are newer drugs for pulmonary fibrosis treatment which may have greater effects but have not got FDA approval yet. Some of the complications are pulmonary hypertension with later right ventricular failure –cor pulmonale and finally respiratory failure.Lung transplant in certain case can be an effective pulmonary fibrosis treatment.
It is fairly clear this is a disease with inferior prognosis and lots of suffering. Many studies are being conducted to find a cure to this illness and only time can tell how successful these would be.
Your living room deserves an amazing home audio system. If you have a comfortable couch and a big flat screen TV, the only thing you’re missing is a loud home audio system. It is the one thing that can change your living room into a home theatre or a music hall. If you are having a party, it can hardly be a success without music. But having said all of that, finding a home audio system that fits your room space and your budget is not very easy to find. So, here is a list of the top home audio systems in the market. If you are looking for a high end acoustic HD sound equipment to give you a theatre-like feel or a low budget one, you will find it on this list. Read along: